Accomplishments: Department of Brain Health

June 19, 2020
Dr. Jeffrey Cummings (Brain Health) recently published an article outlining a novel method for determining whether Alzheimer’s drug treatments in clinical trials are ready to move on to the next phase. The paper, “Translational Scoring of Candidate Treatments for Alzheimer’s Disease: A Systematic Approach,” was published in The Journal of Dementia and Geriatric Cognitive Disorder.  With an estimated 99 percent of drugs in the development pipeline failing, Cummings outlines a semi-qualitative...
May 11, 2020
Dr. Jeffrey Cummings (Brain Health) recently published an article, “The Role of Clinical Trials in Preclinical Alzheimer’s Disease Drug Development Programs," in the Journal of Prevention of Alzheimer’s Disease. The somewhat provocative findings note that despite the trend toward prevention trials becoming more likely (in part because trials in later stages of the disease have failed) they lack many of the essential aspects of successful clinical trials including a well defined target, enough...
April 29, 2020
Dr. Jeffery Cummings (Brain Health) and other members of a joint European Union/United States Task Force recently published, “Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease” in the Journal of Prevention of Alzheimer’s Disease. In recognition of the complexity of the disease, the task force acknowledges it may require multiple agents and may need to start in early disease stage before pathology becomes irreversible. Several alternative approaches may include: tau-...
April 10, 2020
Dr. Jeffrey Cummings (Brain Health), recently published an article, “An Actigraphy-Based Validation Study of the Sleep Disorder Inventory (SDI) in the Nursing Home" in Frontiers in Psychiatry. It studied the use of the SDI to identify disrupted sleep in dementia patients in nursing homes, which was proven to be useful when done properly. According to the study, the SDI’s high internal consistency and convergent validity proves it can serve as a clinical cut-off for the presence of...
April 7, 2020
Dr. Jeffery Cummings (Brain Health) and other members of a joint European Union/United States Task Force recently published, “The Future of Anti-Amyloid Trials,” in the Journal of Prevention and Alzheimer’s Disease. The authors analyze the impact of multiple clinical trials that recently ended for a variety of reasons on the Alzheimer's disease clinical research enterprise. The task force concludes the study of amyloid proteins, while complex, remains a worthwhile undertaking and should not be...
February 19, 2020
Jeffrey Cummings (Brain Health) and co-authors recently published an article proposing brain health be considered a global public health concern that rises to the level of international diplomacy. Their novel approach called brain health innovation diplomacy (BIND) acknowledges the many issues affecting brain health including diet, aging, trauma, and physical activity that require policy-level solutions. In particular, the authors outline a model to maximize the benefits of rapidly advancing...
February 11, 2020
Dr. Jeffrey Cummings (Brain Health) recently published an article, “The Neuropsychiatric Inventory (NPI): Development and Applications,” in the Journal of Geriatric Psychiatry and Neurology. The article reviews the development of the NPI assessment tool since Dr. Cummings first introduced it 25 years ago and which has been used in approximately 350 clinical trials and has been translated into 40 or so languages. The article concludes it remains valid and reliable for capturing behavioral...
November 21, 2019
Samantha John (Brain Health) gave a talk at the National Academy of Neuropsychology 2019 annual conference in San Diego earlier this month. The presentation, "Diagnosis of Posterior Cortical Atrophy Through Inter-Departmental Collaboration," highlighted best practices in the syndromic and pathologic diagnosis of a rare visual variant of Alzheimer's disesase. John coauthored the presentation with colleagues from the Emory University School of Medicine department of neurology, Maria Silva, Nancy...
July 22, 2019
Jefferson Kinney (Integrated Health Sciences) and James Hyman (Psychology) received a $601,576 grant from the National Institute on Aging of the National Institutes of Health for the research project "Aging and Hyperglycemia Alter Molecular Mechanisms and Hippocampal Oscillations Consistent with Alzheimer's Disease."