Accomplishments: Department of Brain Health

October 14, 2021
Kristine Bragg, Gwen Marchand, Jonathan Hilpert (all Educational Psychology and Higher Education), and Jeffrey Cummings (Brain Health) recently published the manuscript, "Using Bibliometrics to Evaluate Outcomes and Influence of Translational Biomedical Research Centers" in the Journal of Clinical and Translational Science.
September 8, 2021
Ryan Wirt, Lauren Crew Andrew Ortiz, and Emmanuel Flores (all Neuroscience), Jefferson Kinney (Brain Health), and James Hyman (Psychology) published an article in Communications Biology entitled "Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer’s disease."  
August 13, 2021
Samantha John (DBrain Health) and colleagues published an investigation of two novel smartphone applications that were developed to assess cognitive functioning, "Examination of the reliability and feasibility of two smartphone applications to assess executive functioning in racially diverse older adults." The manuscript, published in the journal Aging, Neuropsychology, and Cognition, highlights the need for racially unbiased and easily accessible methods for neuropsychological assessment. The...
July 29, 2021
Dr. Jeff Cummings (Brain Health) published "Trial of Pimavanserin in Dementia-Related Psychosis" in the New England Journal of Medicine.       
July 19, 2021
Jeffrey Cummings (Brain Health) co-authored a paper published in Nature on developing the ATX(N) classification, a system for recognizing biomarkers in blood that indicate the presence in the brain of plaques and tangles characteristic of Alzheimer’s disease.  ATX(N) advances allow researchers to diagnose Alzheimer’s disease without imaging or autopsy; the tests may soon become available for clinical use. Cummings is part of the Chambers-Grundy Center for Transformative...
April 26, 2021
Arpita Basu (Kinesiology and Nutrition Sciences); Kenneth Izuora (Medicine); Jefferson Kinney, Arnold Salazar (both Brain Health); and Jeffrey Ebersole (Dental) published a randomized double-blind controlled trial in Nutrients on the effects of strawberry antioxidant supplementation in adults with the metabolic syndrome. The results revealed improvements in diabetes risks with intake of two-and-a-half servings of strawberries daily, which conforms to the USDA guidelines for fruit consumption...
November 23, 2020
Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, and Jefferson W. Kinney (all Brain Health) published a paper titled, “Alterations of GABA B Receptors in the APP/PS1 Mouse Model of Alzheimer’s Disease” in the journal of Neurobiology of Aging. The paper describes the changes occurring in an Amyloid Beta mouse model of Alzheimer's disease that includes cognitive functions and alterations in the GABA B receptors through three timepoints. The paper presents novel specific findings on the...
October 8, 2020
Jefferson Kinney (Brain Health) and James Hyman (Psychology) received a $1.2 million grant from the National Institutes of Aging to continue the research examining the link between Type II diabetes and Alzheimer’s disease. The grant will support them as they continue to investigate the mechanisms underlying Type II diabetes conferring increased risk for developing Alzheimer’s disease, with implications for potential treatments and interventions.  
June 19, 2020
Dr. Jeffrey Cummings (Brain Health) recently published an article outlining a novel method for determining whether Alzheimer’s drug treatments in clinical trials are ready to move on to the next phase. The paper, “Translational Scoring of Candidate Treatments for Alzheimer’s Disease: A Systematic Approach,” was published in The Journal of Dementia and Geriatric Cognitive Disorder.  With an estimated 99 percent of drugs in the development pipeline failing, Cummings outlines a semi-qualitative...
May 11, 2020
Dr. Jeffrey Cummings (Brain Health) recently published an article, “The Role of Clinical Trials in Preclinical Alzheimer’s Disease Drug Development Programs," in the Journal of Prevention of Alzheimer’s Disease. The somewhat provocative findings note that despite the trend toward prevention trials becoming more likely (in part because trials in later stages of the disease have failed) they lack many of the essential aspects of successful clinical trials including a well defined target, enough...
April 29, 2020
Dr. Jeffery Cummings (Brain Health) and other members of a joint European Union/United States Task Force recently published, “Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease” in the Journal of Prevention of Alzheimer’s Disease. In recognition of the complexity of the disease, the task force acknowledges it may require multiple agents and may need to start in early disease stage before pathology becomes irreversible. Several alternative approaches may include: tau-...
April 10, 2020
Dr. Jeffrey Cummings (Brain Health), recently published an article, “An Actigraphy-Based Validation Study of the Sleep Disorder Inventory (SDI) in the Nursing Home" in Frontiers in Psychiatry. It studied the use of the SDI to identify disrupted sleep in dementia patients in nursing homes, which was proven to be useful when done properly. According to the study, the SDI’s high internal consistency and convergent validity proves it can serve as a clinical cut-off for the presence of...