Accomplishments: Department of Brain Health
Jeffrey Cummings (Brain Health) co-authored a paper published in Nature on developing the ATX(N) classification, a system for recognizing biomarkers in blood that indicate the presence in the brain of plaques and tangles characteristic of Alzheimer’s disease. ATX(N) advances allow researchers to diagnose Alzheimer’s disease without…
Arpita Basu (Kinesiology and Nutrition Sciences); Kenneth Izuora (Medicine); Jefferson Kinney, Arnold Salazar (both Brain Health); and Jeffrey Ebersole (Dental) published a randomized double-blind controlled trial in Nutrients on the effects of strawberry antioxidant supplementation in adults with the metabolic syndrome. The results revealed…
Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, and Jefferson W. Kinney (all Brain Health) published a paper titled, “Alterations of GABA B Receptors in the APP/PS1 Mouse Model of Alzheimer’s Disease” in the journal of Neurobiology of Aging. The paper describes the changes occurring in an Amyloid Beta mouse model of Alzheimer's disease…
Jefferson Kinney (Brain Health) and James Hyman (Psychology) received a $1.2 million grant from the National Institutes of Aging to continue the research examining the link between Type II diabetes and Alzheimer’s disease. The grant will support them as they continue to investigate the mechanisms underlying Type II diabetes…
Dr. Jeffrey Cummings (Brain Health) recently published an article outlining a novel method for determining whether Alzheimer’s drug treatments in clinical trials are ready to move on to the next phase. The paper, “Translational Scoring of Candidate Treatments for Alzheimer’s Disease: A Systematic Approach,” was published in The Journal of…
Dr. Jeffrey Cummings (Brain Health) recently published an article, “The Role of Clinical Trials in Preclinical Alzheimer’s Disease Drug Development Programs," in the Journal of Prevention of Alzheimer’s Disease. The somewhat provocative findings note that despite the trend toward prevention trials becoming more likely (in part because trials…
Dr. Jeffery Cummings (Brain Health) and other members of a joint European Union/United States Task Force recently published, “Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease” in the Journal of Prevention of Alzheimer’s Disease. In recognition of the complexity of the disease, the task force acknowledges it may…
Dr. Jeffrey Cummings (Brain Health), recently published an article, “An Actigraphy-Based Validation Study of the Sleep Disorder Inventory (SDI) in the Nursing Home" in Frontiers in Psychiatry. It studied the use of the SDI to identify disrupted sleep in dementia patients in nursing homes, which was proven to be useful when done properly…
Dr. Jeffery Cummings (Brain Health) and other members of a joint European Union/United States Task Force recently published, “The Future of Anti-Amyloid Trials,” in the Journal of Prevention and Alzheimer’s Disease. The authors analyze the impact of multiple clinical trials that recently ended for a variety of reasons on the Alzheimer's disease…
Jeffrey Cummings (Brain Health) and co-authors recently published an article proposing brain health be considered a global public health concern that rises to the level of international diplomacy. Their novel approach called brain health innovation diplomacy (BIND) acknowledges the many issues affecting brain health including diet, aging, trauma,…
Dr. Jeffrey Cummings (Brain Health) recently published an article, “The Neuropsychiatric Inventory (NPI): Development and Applications,” in the Journal of Geriatric Psychiatry and Neurology. The article reviews the development of the NPI assessment tool since Dr. Cummings first introduced it 25 years ago and which has been used in…
Samantha John (Brain Health) gave a talk at the National Academy of Neuropsychology 2019 annual conference in San Diego earlier this month. The presentation, "Diagnosis of Posterior Cortical Atrophy Through Inter-Departmental Collaboration," highlighted best practices in the syndromic and pathologic diagnosis of a rare visual variant of Alzheimer'…