Dr. Jingchun Chen (Nevada Institute of Personalized Medicine) was awarded Mountain West IDeA Clinical and Translational Research — Infrastructure Network (CTR-IN) funding. Her project is titled "Develop a Cellular Model of Microglia for Schizophrenia Research".
In this CTR-IN grant, we propose a pilot study to establish a novel cellular model using monocytes derived directly from living subjects/patients. The feasibility of our proposed cellular model is supported by the fact that new developments in directed differentiation methods allow us to create patient-specific induced pluripotent stem cells (iPSCs) which then can be differentiated into neurons or microglia. The objective of this pilot grant is to establish and validate a cellular model of induced microglia cells that will be used in future study of microglial dysfunction in the development of schizophrenia.