Drs. Edward Lynch and Dr. Martin Grootveld (both Dental) recently published “Mutagenicity Potential of New Atraumatic Restorative Treatment (ART) Materials Incorporated with Azadirachta Indica (Neem) against Salmonella typhimurium” in the international online, open access, peer-reviewed Elsevier Journal of Oral Biology and Craniofacial Research.
The collaborative study included faculty from UNLV School of Dental Medicine; NITTE University department of oral biology and genomic studies, India; the global child dental health unit in Kings College London; and the bioanalytical chemistry and chemical pathology in the biomedical & environmental health department in De Montfort University, United Kingdom.
The project used the Ames test (genotoxicity) to study the mutagenicity potential of two new atraumatic restorative treatment (ART) materials against Salmonella typhimurium without metabolic activity. Both ART materials exhibited weak mutagenic effects on S. typhimurium TA98, whereas no mutagenic effect was detected on S. typhimurium TA100.