Genetic studies have made significant progress in recent years. One of the major findings is that all human traits, including many heath related traits, such as disease predisposition, treatment response, relapse and side effect, are all influenced by genetic makeup. This makes the dissection of individual’s genome a necessary and essential task in order to achieve the best effects of disease prevention, diagnosis, and treatment. In this personalized medicine focused COBRE application, the Genome Acquisition and Analysis core is designed to help and support individual projects to acquire genomics and genetics data and integrate these data for the projects so that each project can accomplish its goals in personalized characterization and analysis of focused health issues. The central goals of the genomics acquisition and analysis (GAA) core are to support individual and pilot research projects by providing services and education for DNA and RNA sequencing, data processing, storage, management and protection, data integration and dissemination, and bioinformatic and statistical analyses. The research projects and pilot projects will produce and analyze a large amount of genomic and genetic data, therefore will need high-performance computational resources. The core will provide technical support for the RPs to safeguard their data and protect study subjects according to federal policies. The GAA core is committed to educating our investigators and students through a series of workshops and seminars, hands-on training, peer-to-peer interaction, and national and international conferences.