My laboratory focuses on the study of mutagenesis in cells under conditions of no-growth or under nutritional stress. We use Bacillus subtilis as a model to elucidate novel mechanisms that produce genetic diversity in conditions of stress. Particularly, we are interested in mutagenesis that is mediated by the process of transcription. These processes are influenced by universally conserved factors, provide novel views of the evolutionary process and apply to the formation of mutations in all organisms.
My research focuses on identifying novel mechanisms of mutation. I am particularly interested in elucidating cellular processes that generate mutations in non-replicating cells. These processes are important in evolution and apply to the acquisition of antibiotic resistance in human pathogens and to the formation of tumors in differentiated tissue.
Microbiology, DNA Repair and Mutagenesis, Bacterial Genetics