My research activities focus on ontogeny of physiological regulatory mechanisms and their plasticity with a focus on the cardio-respiratory systems. This paradigm encompasses the idea that animals develop the physiological regulatory machinery necessary to meet immediate metabolic demands encountered during defined developmental stages. As metabolic demand changes the animals compensate physiologically, morphologically and behaviorally (plasticity) to meet the new challenges. The general goals of my research are to establish a more thorough understanding of the physiological and ontogenetic mechanisms that allow the heart and circulatory system to provide for appropriate blood supply to meet metabolic demands during exposure to environmental stress. This research is based on a comparative approach, using animals that best demonstrate relevant physiological functions, which has also led to cross-taxonomic comparisons, allowing for a better understanding of evolutionary and environmental relationships. Over the past few years, we have moved from questions based on the physiological mechanisms of cardiac and respiratory regulation to a more integrative approach that encompasses multiple levels of organization and ranging from the physiological systems (organ system level) through to cellular and molecular levels of function. This slight shift in direction has been “question” driven and will allow our laboratory to investigate mechanistic issues as new questions evolve.
Current areas of active research include: (1) limits to cardiac function in response to temperature in the grass shrimp (Paleamonetes pugio), (2) the HIF1a mediated mechanisms of hypoxia tolerance in Triops longicaudatus, specifically, the regulation of hemoglobin isoforms and the metabolic down-regulation of cardiac tissue which allows hypoxic tolerance and survival (3) neurohormonal control of cardiac function and adaptations of the cardio-respiratory systems to hypoxic stresses and (4) the evolutionary origins of the vascular endothelia and its physiological function with regard to hemodynamics, transport and vascular development.
Ph.D. University of Massachusetts, Amherst (1992)
- Guadangoli, J.A., L. Tobita, and C.L. Reiber. 2011. Changes in cardiac performance
during hypoxic exposure in the grass shrimp, Paleamonetes pugio. J. Exp. Biol. 214: 3906-3914.
- Reiber, C.L. and I.J. McGaw. 2009. A review of the “open” and “closed” circulatory systems: New terminology for complex invertebrate circulatory systems in light of current findings. International J. Zoology. 2009: 301204.
- Guadangoli, J.A., L. Tobita, and C.L. Reiber. 2007. Assessment of the pressure area relationship of the single ventricle of the grass shrimp Paleamonetes pugio. J. Exp. Biol. 210: 2192-2198.
- Harper, S.L. and C.L. Reiber. 2006. Metabolic, respiratory and cardiovascular responses to acute and chronic hypoxic exposure in tadpole shrimp, Triopslongicaudatus. J. Exp. Biol. 209: 1639-1650.
- Harper, S.L. and C.L. Reiber. 2006. Ontogeny of cardiac physiology and aerobic metabolism in the red swamp crayfish Procambarus clarkii. J. Comp. Physiol. B. 176(5): 405-414.
- Guadagnoli, J.A., L. Jones and C.L. Reiber. 2005. The influence of reproductive state on cardiac parameters and hypoxia tolerance in the grass shrimp Palaemonetespugio. J. Functional Ecology 19(6): 976-981.