In July 2022, a bombshell dropped on the Alzheimer's disease research field. For years, researchers had searched for something that caused the disease’s telltale amyloid plaques — complex tangles of a protein called amyloid-beta (Aβ) frequently found in the brains of patients with neurodegenerative disorders. A series of studies published starting in the mid-2000s reported the discovery of a toxic form of Aβ in the brains of mouse models of Alzheimer's disease called Aβ*56. Researchers hoped that Aβ*56 was the protein that snowballed into those amyloid plaques. But a team of sleuths found that many of the papers describing Aβ*56 were fraudulent and contained an array of faked images and blots. The fraud seemed to call the entire idea of amyloids causing Alzheimer’s disease into question.

The number, while impressive and encouraging for local tourism officials, still falls short of the record 42.9 million in 2016 and 42.5 million in 2019, the last year before Covid-19 broadly affected travel and tourism.

Sunday’s edition of the Super Bowl will be historic in a handful of ways, including being the first NFL title game to feature two Black starting quarterbacks and the first to be held in a state — in this instance, Arizona — with legal sports betting. But by the time the 2025 Super Bowl reaches its conclusion, at least one of these milestones (and possibly both) will feel like business as usual.