Please join us for the Statistics Seminar, joint seminar with NIPM,  scheduled from 11:45 a.m. to 1 p.m. on Friday, November 8.

Speaker: Russell Takeshi Shinohara, professor of biostatistics & epidemiology, Perelman School of Medicine, University of Pennsylvania, 2023 Moritmer Spiegelman Award Recipient

Title: Harmonizing neuroimaging data acquired in multi-center studies of human health

Abstract:

While magnetic resonance imaging (MRI) studies are critical for the diagnosis, monitoring, and study of a wide variety of diseases, their use in quantitative analysis can be complex. An increasingly recognized issue involves the differences between MRI scanners that are used in large multi-center studies. To address this, the current state of the art is to "regress out" or "adjust for'" scanner differences. The field has found these methods to be insufficient and has advocated for the adaptation of methods pioneered in genomics to help mitigate inter-scanner differences, which can vary across the brain and result in both mean and variance shifts. We further study the implications of differences in correlation structures across and between images, and how this affects downstream inference.

Zoom information: (Also audience can attend in person at HOS 382)

Meeting ID: 979 2207 3178

Passcode: 47531594