COBRE Grant Supplement Awarded $373,737 for Alzheimer's Research

Sep. 1, 2019

NIPM was awarded a $373,737 COBRE grant supplement by the NIH National Institute of General Medical Sciences for the project, "COBRE Supplement: TREM2 atlas of mutations and TREM2 positive exosomes as Alzheimer's markers."  The funds will be used to investigate two pilot projects examining the genetics of Alzheimer's Disease, in a collaboration with the Center for Neurodegenerative and Translational Neuroscience COBRE (CNTN), a multidisciplinary enterprise with inter-disciplinary networks, housed in the Cleveland Clinic Lou Ruvo Center for Brain Health and the University of Nevada Las Vegas.  Late Onset Alzheimer’s Disease (LOAD) is a genetic disorder with heritability estimates of about 80%, and in preliminary studies, our Genomic Acquisition and Analysis (GAA) core has sequenced the exomes of the LOAD cohort.  The pilot projects will build two key resources creating an atlas of TREM2 variants with their impact of signaling as a surrogate for AD pathogenesis, and generating immortalized cell lines for the LOAD cohort.