UNLV American Society for Microbiology (ASM) Seminar Series: Dr. Corrie Detweiler

When

Jan. 20, 2017, 1pm to 2:15pm

Office/Remote Location

White TAuditorium (197)

Description

The UNLV American Society for Microbiology (ASM) Student Chapter invites a speaker to present at the Biology Friday Seminar Series each year.

Dr. Corrie Detweiler, from the University of Colorado Boulder, will deliver a lecture titled, A Chemical Genetics Approach to Bacterial Pathogenesis. Dr. Detweiler's research investigates the pressing unmet need for new antibiotics, particularly for Gram-negative bacterial pathogens. To identify probes of the host-pathogen interface that may have antibiotic potential, we developed a quantitative, high throughput, phenotypic screen for small molecules that prevent the growth of Salmonella enterica in macrophages, a kind of white blood cell that kills non-pathogenic bacteria. We screened the 14,400 compounds of the Maybridge HitFinder Library, a collection of compounds with drug-like properties. This approach identified 70 compounds that reduce bacterial load but were not previously known to have antibacterial activity. We verified 60 of the hits in a secondary screen that quantifies bacterial colony form­ing units by plating lysed macrophages. Only three of these hits inhibited bacterial growth in standard microbiological media, indicating the remain­der function specifically in the context of an infected macrophage. I will describe the screening platform and present the results of our recent studies characterizing top hits.

Admission Information

This event is free and open to the public.

Contact Information

UNLV ASM Student Chapter
Holly Martin

External Sponsor

The UNLV American Society for Microbiology (ASM) Student Chapter