Role of Microglia in Schizophrenia and Autoimmune Disorders

Research Project 3 led by Jingchun Chen will investigate the functional role of microglia and immune system dysfunction in schizophrenia etiology to help identify new genetic markers for subtyping schizophrenia and to develop new therapeutic strategies. Studies have shown that there is a strong association between schizophrenia, autoimmune disorders, and inflammation. A large body of evidence also shows that immune cells, like microglia in the brain, are the major mediators in the development of schizophrenia. Here, we are studying the genetic relationship between schizophrenia and autoimmune disorders. We will also investigate the role of microglia in schizophrenia.