Nov. 28, 2022

 

Please join us for the next NIPM Seminar on Thursday, December 1, 2022, from 12:00pm - 1:30pm with Andrey S. Tsvetkov, Ph.D. Associate Professor Department of Neurology from University of Texas Medical School at Houston

Title of talk: Sex differences in age-associated diseases

Abstract provided by Andrey S. Tsvetkov, Ph.D.

Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients.

Location: UNLV HRC Conference Room, 1st Floor

Zoom: https://us02web.zoom.us/j/84602088451?pwd=MG1ZM1JTallKeEVRSzI2YXByQk9aZz09
Meeting ID: 846 0208 8451
Passcode: 985558