Ann Vuong, DrPH, MPH, Assistant Professor in the Department of Epidemiology and Biostatistics in the School for Public Health, was awarded a $2.4M grant from the National Institutes of Health. The NIH grant will allow Vuong to further her research on the project Early Life Organophosphate Ester (OPE) Exposures and Adiposity and Cardiometabolic Health during Adolescence.
The five-year NIH award is Vuong’s first as PI at UNLV and will explore the widespread use of organophosphate esters (OPEs) as flame retardants has resulted in ubiquitous exposure, which have been observed to impact lipid levels, disrupt metabolic function, and impair glucose tolerance in toxicological studies, supporting OPEs as obesogenic and metabolism-disrupting chemicals.
The project will utilize the Health Outcomes and Measures of the Environment (HOME) Study to examine whether early life OPE exposures, from gestation to adolescence, are associated with adiposity and cardiometabolic health outcomes in adolescence at 12 years using repeated measurements of OPEs to identify periods of susceptibility, while also using advanced statistical methods to account for complex OPE mixtures.
The term of the grant is September 21, 2022 – July 31, 2027.
Ann Vuong's pilot project on "Early life exposure to flame retardants and kidney function in adolescence" was funded by the Mountain West Clinical and Translational Infrastructure Network for $66,000.
Data from the Health Outcomes and Measures of the Environment (HOME) Study will be used to examine whether early life exposure to polybrominated diphenyl ether (PBDE) and organophospate ester (OPE) metabolites, from gestation to adolescence, are associated with kidney function in adolescence at 12 years.
Ann Vuong co-published an article titled, "Postprandial changes of oxidative stress biomarkers in healthy individuals," in the journal Frontiers in Nutrition.
This study aimed to examine the postprandial changes of fluorescent oxidation products, malondialdehyde, total antioxidant capacity, and Superoxide dismutase in healthy individuals following a regular diet. Understanding the postprandial changes of oxidative stress may help prevent food-induced oxidative damage. This study will also help refine the timing of blood sample collection for accurately measuring oxidative stress levels in humans.