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Mira Han

Assistant Professor
School of Life Sciences
Office: SEB 3178
Phone: 702-774-1503
Fax: 702-895-3956

Biography

The Han lab studies the evolution of genome structure. We use bioinformatics to investigate how genomes change through gene duplication, loss and gene transpositions. We also are interested in the phenotypic effects of Copy Number Variations (CNVs), indels and transposable element polymorphisms.

Expertise

Molecular Evolution, Bioinformatics, Computational Biology

Selected Publications

  • Han, M. V., Thomas, G. W., Lugo-Martinez, J. & Hahn, M. W. Estimating gene gain and loss rates in the presence of error in genome assembly and annotation using CAFE 3. Mol Biol Evol(2013).
  • Han, M. V. & Hahn, M. W. Inferring the history of interchromosomal gene transposition in Drosophila using n-dimensional parsimony. Genetics 190, 813–825 (2012).
  • Han, M. V. Characterizing gene movements between chromosomes in Drosophila. Fly 6, 121–125 (2012).
  • Chen, S. et al. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat Comms 3, 913 (2012).
  • Snell Rood, E. C. et al. Developmental decoupling of alternative phenotypes: Insights from the transcriptomes of horn-polyphenic beetles. Evolution 65, 231–245 (2011).
  • Moyle, L. C., Muir, C. D., Han, M. V. & Hahn, M. W. The contribution of gene movement to the ‘two rules of speciation’. Evolution 64, 1541–1557 (2010).
  • Lu, Y.-K. et al. Metabolic flexibility revealed in the genome of the cyst-forming ?-1 proteobacterium Rhodospirillum centenum. BMC Genomics 11, 325 (2010).
  • Han, M. V. & Zmasek, C. phyloXML: XML for evolutionary biology and comparative genomics.BMC Bioinformatics 10, 356 (2009).
  • Han, M. V., Demuth, J. P., McGrath, C. L., Casola, C. & Hahn, M. W. Adaptive evolution of young gene duplicates in mammals. Genome Res. 19, 859–867 (2009).
  • Meisel, R. P., Han, M. V. & Hahn, M. W. A complex suite of forces drives gene traffic from Drosophila X chromosomes. Genome Biology and Evolution 1, 176 (2009).
  • Han, M. V. & Hahn, M. W. Identifying parent-daughter relationships among duplicated genes.Pacific Symposium on Biocomputing 14, 114–125 (2009).
  • Costello, J. C., Han, M. V. & Hahn, M. W. Limitations of pseudogenes in identifying gene losses. 14–25 (2008).
  • Clark, A. G. et al. Evolution of genes and genomes on the Drosophila phylogeny.: Drosophila 12 Genomes Consortium. Nature 450, (2007).
  • Stark, A. et al. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 450, 219–232 (2007).
  • Hahn, M. W., Han, M. V. & Han, S.-G. Gene family evolution across 12 Drosophila genomes.PLoS Genet 3, e197 (2007).